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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not, be used to replace the need for explanation studies.

The pragmatism idea is controversial, 프라그마틱 무료 - https://ahdivan.ru - and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic trial that include the recruitment process, the design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatics. It is important to note, however, that the majority of studies were conducted in primary-care settings.